This study examines the effectiveness of combined Non-Linear Scanning (NLS) techniques in diagnosing space-occupying lesions of the eye and orbit. Sixty patients with suspected ocular tumors underwent comprehensive evaluation using 2D and 3D NLS imaging, ultramicroscanning, angiography, and spectral-entropic analysis. The approach improved detection and characterization of conditions such as retinoblastoma, uveal melanoma, hemangioma, glioma, lymphosarcoma, and lacrimal gland tumors. Three-dimensional NLS reconstruction enabled precise visualization of tumor size, structure, vascular supply, and relationships with surrounding ocular tissues in real time. Spectral-entropic analysis enhanced differential diagnosis and helped distinguish tumors from similar pathological conditions. Compared with conventional 2D imaging, full-scale 3D NLS significantly increased diagnostic accuracy and provided more detailed information for treatment planning. The findings highlight the value of advanced NLS technologies as a powerful complementary tool in ophthalmic oncology and orbital tumor assessment.

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